HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

Abstract Background HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lymphopenia and immune activation affect malaria-specific antibody respons...

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Bibliographic Details
Main Authors: Eliud O. Odhiambo, Dibyadyuti Datta, Bernard Guyah, George Ayodo, Bartholomew N. Ondigo, Benard O. Abong’o, Chandy C. John, Anne E. P. Frosch
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Malaria Journal
Subjects:
HIV
Plasmodium falciparum
Antibodies
Immune activation
Viral load
CRP
Online Access:http://link.springer.com/article/10.1186/s12936-019-2915-7

Internet

http://link.springer.com/article/10.1186/s12936-019-2915-7

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