Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice

Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice

Abstract Background In acute ischemic stroke, cessation of blood flow causes immediate tissue necrosis within the center of the ischemic brain region accompanied by functional failure in the surrounding brain tissue designated the penumbra. The penumbra can be salvaged by timely thrombolysis/thrombe...

Full description

Bibliographic Details
Main Authors:	Michael K. Schuhmann, Michael Bieber, Maximilian Franke, Alexander M. Kollikowski, David Stegner, Katrin G. Heinze, Bernhard Nieswandt, Mirko Pham, Guido Stoll
Format:	Article
Language:	English
Published:	BMC 2021-02-01
Series:	Journal of Neuroinflammation
Subjects:	Ischemic penumbra Glycoprotein receptor Ib T-cells Ischemic stroke Thrombo-inflammation middle cerebral artery occlusion
Online Access:	https://doi.org/10.1186/s12974-021-02095-1

Similar Items

Platelets as Modulators of Cerebral Ischemia/Reperfusion Injury
by: David Stegner, et al.
Published: (2019-11-01)

Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice
by: Michael K. Schuhmann, et al.
Published: (2019-04-01)

Cerebral Ischemia Increases Small Ubiquitin-Like Modifier Conjugation within Human Penumbral Tissue: Radiological–Pathological Correlation
by: Joshua D. Bernstock, et al.
Published: (2018-01-01)

Quantitative Proteomics Reveals the Beneficial Effects of Low Glucose on Neuronal Cell Survival in an in vitro Ischemic Penumbral Model
by: Hua Li, et al.
Published: (2020-09-01)

Management of Blood Pressure During and After Recanalization Therapy for Acute Ischemic Stroke
by: Jeffrey R. Vitt, et al.
Published: (2019-02-01)

Blood Pressure and Penumbral Sustenance in Stroke from Large Vessel Occlusion
by: Robert W. Regenhardt, et al.
Published: (2017-07-01)

Magnetic Resonance Imaging of Ischemia Viability Thresholds and the Neurovascular Unit
by: Philip A. Barber
Published: (2013-05-01)

Morphometric characteristics of acute swelling and induration of neurons in the critical zone of ischemic brain infarction
by: T. V. Shulyatnikova
Published: (2012-12-01)

Sensory Stimulation-Induced Astrocytic Calcium Signaling in Electrically Silent Ischemic Penumbra
by: Reena P. Murmu, et al.
Published: (2019-08-01)

Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain
by: L.A. Favero-Filho, et al.
Published: (2008-11-01)

Unraveling the Specific Ischemic Core and Penumbra Transcriptome in the Permanent Middle Cerebral Artery Occlusion Mouse Model Brain Treated with the Neuropeptide PACAP38
by: Motohide Hori, et al.
Published: (2015-01-01)

HYPERHOMOCYSTEINEMIA, A BIOCHEMICAL TOOL FOR ISCHEMIC VEIN OCCLUSION DURING ACUTE PHASE
by: Bassam Mubarik, et al.
Published: (2018-06-01)

Embolization of medium-sized vessels with the penumbra occlusion device: evaluation of anchoring function
by: Kenichi Kato, et al.
Published: (2020-05-01)

Therapeutic occlusion of the vertebral artery using a new penumbra occlusion device system and ruby coils (penumbra): A technical note
by: Jay P Kinariwala, et al.
Published: (2020-01-01)

Collaterals: an Important Determinant of Prolonged Ischemic Penumbra versus Rapid Cerebral Infarction?
by: Elisabeth Breese Marsh, et al.
Published: (2014-10-01)

Central retinal vein occlusion and pseudoexfoliation syndrome
by: Karagiannis D, et al.
Published: (2015-05-01)

von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke
by: Frederik Denorme, et al.
Published: (2019-12-01)

Retinal vein occlusion
by: Hayreh Sohan
Published: (1994-01-01)

Immune Cells Invade the Collateral Circulation during Human Stroke: Prospective Replication and Extension
by: Marc Strinitz, et al.
Published: (2021-08-01)

Evidence and opportunities of hypothermia in acute ischemic stroke: Clinical trials of systemic versus selective hypothermia
by: Christian Huber, et al.
Published: (2019-01-01)

Machine learning-based segmentation of ischemic penumbra by using diffusion tensor metrics in a rat model
by: Duen-Pang Kuo, et al.
Published: (2020-07-01)

Multiphase adjuvant neuroprotection: A novel paradigm for improving acute ischemic stroke outcomes
by: Wenbo Zhao, et al.
Published: (2020-01-01)

Identification of penumbra in acute ischemic stroke using multimodal MR imaging analysis: A case report study
by: Forough Sodaei, MSc, et al.
Published: (2020-10-01)

Baseline Cerebral Ischemic Core Quantified by Different Automatic Software and Its Predictive Value for Clinical Outcome
by: Zhang Shi, et al.
Published: (2021-04-01)

Neuroprotective Effect of IRL-1620, an Endothelin B Receptor Agonist, on a Pediatric Rat Model of Middle Cerebral Artery Occlusion
by: Enrique G. Cifuentes, et al.
Published: (2018-10-01)

Hyperbaric oxygen therapy after acute ischemic stroke with large penumbra: a case report
by: Omar Hussein, et al.
Published: (2020-09-01)

Diffusion-Perfusion Mismatch: An Opportunity for Improvement in Cortical Function
by: Melissa eMotta, et al.
Published: (2015-01-01)

Perfusion-Based Decision-Making for Mechanical Thrombectomy in a Transient Ischemic Attack Patient with Middle Cerebral Artery Occlusion
by: Thang Huy Nguyen, et al.
Published: (2020-12-01)

The Spatiotemporal Evolution of MRI-Derived Oxygen Extraction Fraction and Perfusion in Ischemic Stroke
by: Di Wu, et al.
Published: (2021-08-01)

Ischemic Strokes Due to Large-Vessel Occlusions Contribute Disproportionately to Stroke-Related Dependence and Death: A Review
by: Konark Malhotra, et al.
Published: (2017-11-01)

Immunohistological Analysis of Neutrophils and Neutrophil Extracellular Traps in Human Thrombemboli Causing Acute Ischemic Stroke
by: Fabian Essig, et al.
Published: (2020-10-01)

Quantitative Measurement of Cerebral Perfusion with Intravoxel Incoherent Motion in Acute Ischemia Stroke: Initial Clinical Experience
by: Li-Bao Hu, et al.
Published: (2015-01-01)

The Ischemic Penumbra: Still the Target for Acute Stroke Therapies
by: Argye E. Hillis
Published: (2015-04-01)

The Value of Susceptibility-Weighted Imaging (SWI) in Evaluating the Ischemic Penumbra of Patients with Acute Cerebral Ischemic Stroke
by: Wang YR, et al.
Published: (2021-06-01)

Multimodal Optical Imaging to Investigate Spatiotemporal Changes in Cerebrovascular Function in AUDA Treatment of Acute Ischemic Stroke
by: Han-Lin Wang, et al.
Published: (2021-06-01)

Quantitative measurement of vascular density and flow using optical coherence tomography angiography (OCTA) in patients with central retinal vein occlusion: Can OCTA help in distinguishing ischemic from non-ischemic type?
by: Alireza Khodabandeh, et al.
Published: (2018-12-01)

Treatment with Edoxaban Attenuates Acute Stroke Severity in Mice by Reducing Blood–Brain Barrier Damage and Inflammation
by: Michael Bieber, et al.
Published: (2021-09-01)

“Thrombectomy and Back:” A novel approach for treating patients with large vessel occlusion in the Eastern Province of Saudi Arabia
by: Hosam Al-Jehani, et al.
Published: (2021-01-01)

Influence and reliability of lower-limb arterial occlusion pressure at different body positions
by: Luke Hughes, et al.
Published: (2018-05-01)

FGB -455 G>A and GP IIIa PIA1/A2 polymorphisms in a group of Romanian stroke patients
by: Petrişor Felicia Maria, et al.
Published: (2016-03-01)