Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice

Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice

Abstract Background In acute ischemic stroke, cessation of blood flow causes immediate tissue necrosis within the center of the ischemic brain region accompanied by functional failure in the surrounding brain tissue designated the penumbra. The penumbra can be salvaged by timely thrombolysis/thrombe...

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Bibliographic Details
Main Authors: Michael K. Schuhmann, Michael Bieber, Maximilian Franke, Alexander M. Kollikowski, David Stegner, Katrin G. Heinze, Bernhard Nieswandt, Mirko Pham, Guido Stoll
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Neuroinflammation
Subjects:
Ischemic penumbra
Glycoprotein receptor Ib
T-cells
Ischemic stroke
Thrombo-inflammation
middle cerebral artery occlusion
Online Access:https://doi.org/10.1186/s12974-021-02095-1

Internet

https://doi.org/10.1186/s12974-021-02095-1

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