Mechanisms responsible for the inhibitory effects of epothilone B on scar formation after spinal cord injury

Mechanisms responsible for the inhibitory effects of epothilone B on scar formation after spinal cord injury

Scar formation after spinal cord injury is regarded as an obstacle to axonal regeneration and functional recovery. Epothilone B provides moderate microtubule stabilization and is mainly used for anti-tumor therapy. It also reduces scar tissue formation and promotes axonal regeneration after spinal c...

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Bibliographic Details
Main Authors: Wei Zhao, Yong Chai, Yun Hou, Da-wei Wang, Jian-qiang Xing, Cheng Yang, Qing-min Fang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; spinal cord injury; epothilone B; pericytes; gene expression; fibrous scar; β-tubulin; platelet-derived growth factor receptor β; neuron-glial antigen 2; fibronectin; glial fibrillary acidic protein; rats; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=3;spage=478;epage=485;aulast=Zhao

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=3;spage=478;epage=485;aulast=Zhao

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