Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway

Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway

Berberine (BBR) has a neuroprotective effect against ischemic stroke, but its specific protective mechanism has not been clearly elaborated. This study explored the effect of BBR on the canopy FGF signaling regulator 2 (CNPY2) signaling pathway in the ischemic penumbra of rats. The model of cerebral...

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Bibliographic Details
Main Authors: Lina Zhao, Huanming Li, Qian Gao, Jin Xu, Yongjie Zhu, Meili Zhai, Peijun Zhang, Na Shen, Yanbo Di, Jinhui Wang, Tie Chen, Meina Huang, Jinglai Sun, Chong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
berberine
cerebral ischemia-reperfusion injury
apoptosis
CNPY2
pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.609693/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.609693/full

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