Honokiol, a Polyphenol Natural Compound, Attenuates Cisplatin-Induced Acute Cytotoxicity in Renal Epithelial Cells Through Cellular Oxidative Stress and Cytoskeleton Modulations

Honokiol, a Polyphenol Natural Compound, Attenuates Cisplatin-Induced Acute Cytotoxicity in Renal Epithelial Cells Through Cellular Oxidative Stress and Cytoskeleton Modulations

Cisplatin is a potent anti-cancer drug that has been widely used in the treatment of various cancers; however, cisplatin administration results in severe nephrotoxicity and impedes its clinical applications. In this study, we showed that honokiol, a polyphenol constituent extracted from Magnolia off...

Full description

Bibliographic Details
Main Authors: Tse-En J. Wang, Hung-Ting Liu, Yu-Hua Lai, Tong-Rong Jan, Naohiro Nomura, Hui-Wen Chang, Chi-Chung Chou, Ya-Jane Lee, Pei-Shiue J. Tsai
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
honokiol
cisplatin
kidney
cytoskeleton
oxidative stress
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00357/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00357/full

Similar Items