Synthesis and in Vitro Antitumor Activity of a Novel Series of 2-Pyrazoline Derivatives Bearing the 4-Aryloxy-7-chloroquinoline Fragment

Synthesis and in Vitro Antitumor Activity of a Novel Series of 2-Pyrazoline Derivatives Bearing the 4-Aryloxy-7-chloroquinoline Fragment

A new series of NH-pyrazoline derivatives 6 was synthesized by cyclocondensation reaction of novel [(7-chloroquinolin-4-yl)oxy]chalcones 5 with hydrazine hydrate. The treatment of pyrazolines 6 with acetic anhydride or formic acid yielded the N-acetyl- or N-formylpyrazoline derivatives 7–8, respect...

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Bibliographic Details
Main Authors: Alba Montoya, Jairo Quiroga, Rodrigo Abonia, Manuel Nogueras, Justo Cobo, Braulio Insuasty
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
microwave irradiation
Claisen-Schmidt condensation
chalcones
cyclocondensation reaction
2-pyrazolines
antitumor activity
Online Access:http://www.mdpi.com/1420-3049/19/11/18656

Internet

http://www.mdpi.com/1420-3049/19/11/18656

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