Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice

Components of the seminal fluid are required for specific gene expression and immune changes in the uterus following mating, but the role that sperm play in this process has remained unclear. Here, John Schjenken et al. compare female mice mated to intact and vasectomized males and show that sperm a...

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Main Authors:	John E. Schjenken, David J. Sharkey, Ella S. Green, Hon Yeung Chan, Ricky A. Matias, Lachlan M. Moldenhauer, Sarah A. Robertson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-05-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02038-9

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spelling	doaj-84058944357844abadb2a9c35f93e1282021-05-16T11:21:27ZengNature Publishing GroupCommunications Biology2399-36422021-05-014111410.1038/s42003-021-02038-9Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in miceJohn E. Schjenken0David J. Sharkey1Ella S. Green2Hon Yeung Chan3Ricky A. Matias4Lachlan M. Moldenhauer5Sarah A. Robertson6The Robinson Research Institute and Adelaide Medical School, University of AdelaideThe Robinson Research Institute and Adelaide Medical School, University of AdelaideThe Robinson Research Institute and Adelaide Medical School, University of AdelaideThe Robinson Research Institute and Adelaide Medical School, University of AdelaideThe Robinson Research Institute and Adelaide Medical School, University of AdelaideThe Robinson Research Institute and Adelaide Medical School, University of AdelaideThe Robinson Research Institute and Adelaide Medical School, University of AdelaideComponents of the seminal fluid are required for specific gene expression and immune changes in the uterus following mating, but the role that sperm play in this process has remained unclear. Here, John Schjenken et al. compare female mice mated to intact and vasectomized males and show that sperm are required for the full post-mating response, indicating a broader role for sperm in reproduction beyond fertilization.https://doi.org/10.1038/s42003-021-02038-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	John E. Schjenken David J. Sharkey Ella S. Green Hon Yeung Chan Ricky A. Matias Lachlan M. Moldenhauer Sarah A. Robertson
spellingShingle	John E. Schjenken David J. Sharkey Ella S. Green Hon Yeung Chan Ricky A. Matias Lachlan M. Moldenhauer Sarah A. Robertson Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice Communications Biology
author_facet	John E. Schjenken David J. Sharkey Ella S. Green Hon Yeung Chan Ricky A. Matias Lachlan M. Moldenhauer Sarah A. Robertson
author_sort	John E. Schjenken
title	Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice
title_short	Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice
title_full	Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice
title_fullStr	Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice
title_full_unstemmed	Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice
title_sort	sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-05-01
description	Components of the seminal fluid are required for specific gene expression and immune changes in the uterus following mating, but the role that sperm play in this process has remained unclear. Here, John Schjenken et al. compare female mice mated to intact and vasectomized males and show that sperm are required for the full post-mating response, indicating a broader role for sperm in reproduction beyond fertilization.
url	https://doi.org/10.1038/s42003-021-02038-9
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Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice

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