CCR2 Mediates Chronic LPS-Induced Pulmonary Inflammation and Hypoalveolarization in a Murine Model of Bronchopulmonary Dysplasia

CCR2 Mediates Chronic LPS-Induced Pulmonary Inflammation and Hypoalveolarization in a Murine Model of Bronchopulmonary Dysplasia

The histopathology of bronchopulmonary dysplasia (BPD) includes hypoalveolarization and interstitial thickening due to abnormal myofibroblast accumulation. Chorioamnionitis and sepsis are major risk factors for BPD development. The cellular mechanisms leading to these lung structural abnormalities a...

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Bibliographic Details
Main Authors: Tracy X. Cui, Alexander E. Brady, Christina T. Fulton, Ying-Jian Zhang, Liza M. Rosenbloom, Adam M. Goldsmith, Bethany B. Moore, Antonia P. Popova
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
prematurity
bronchopulmonary dysplasia
inflammation
macrophages
CCR2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.579628/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.579628/full

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