Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)

Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)

An increasing body of evidence associates low vitamin D levels with increased risk of multiple sclerosis (MS), suggesting the possibility of a gene-environment interaction for this environmental factor in MS pathogenesis. Moreover, it has been shown that vitamin D downregulates major histocompatibil...

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Bibliographic Details
Main Authors: Sonja Hochmeister, Shahin Aeinehband, Charles Dorris, Rasmus Berglund, Michaela T. Haindl, Vid Velikic, Sven A. Gustafsson, Tomas Olsson, Fredrik Piehl, Maja Jagodic, Manuel Zeitelhofer, Milena Z. Adzemovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neurology
Subjects:
CIITA (Mhc2ta)
vitamin D
experimental autoimmune encephalomyelitis (EAE)
multiple sclerosis (MS)
allelic variant
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.600401/full

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https://www.frontiersin.org/articles/10.3389/fneur.2020.600401/full

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