Aortic dissection is associated with reduced polycystin-1 expression, an abnormality that leads to increased ERK phosphorylation in vascular smooth muscle cells

<p>The vascular smooth muscle cell (VSMC) phenotypic switch is a key pathophysiological change in various cardiovascular diseases, such as aortic dissection (AD), with a high morbidity. Polycystin-1 (PC1) is significantly downregulated in the VSMCs of AD patients. PC1 is an integral membrane g...

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Bibliographic Details
Main Authors: J. Feng, S. Ge, L. Zhang, H. Che, C. Liang
Format: Article
Language:English
Published: PAGEPress Publications 2016-12-01
Series:European Journal of Histochemistry
Subjects:
ERK
Online Access:http://www.ejh.it/index.php/ejh/article/view/2711