Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels

Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels

Abstract Background The genetic architecture of Parkinson’s Disease (PD) is complex and not completely understood. Multiple genetic studies to date have identified multiple causal genes and risk loci. Nevertheless, most of the expected genetic heritability remains unexplained. Polygenic risk scores...

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Bibliographic Details
Main Authors: Laura Ibanez, Umber Dube, Benjamin Saef, John Budde, Kathleen Black, Alexandra Medvedeva, Jorge L. Del-Aguila, Albert A. Davis, Joel S. Perlmutter, Oscar Harari, Bruno A. Benitez, Carlos Cruchaga
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Neurology
Subjects:
Parkinson disease
Genetics
Age at onset
Biomarkers
Polygenic risk score
Online Access:http://link.springer.com/article/10.1186/s12883-017-0978-z

Internet

http://link.springer.com/article/10.1186/s12883-017-0978-z

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