Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases

Abstract T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysr...

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Bibliographic Details
Main Authors: He Hao, Shingo Nakayamada, Yoshiya Tanaka
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Inflammation and Regeneration
Subjects:
Online Access:https://doi.org/10.1186/s41232-021-00164-9