Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats

Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats

Abstract In clinical pharmacology, the free drug hypothesis has been widely applied in the interpretation of the relationship between pharmacokinetics and pharmacodynamics (PK/PD). The free drug hypothesis assumes that the unbound drug concentration in blood is the same as that in the site of action...

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Bibliographic Details
Main Authors: Chun Chen, Hongyu Zhou, Chi Guan, Huanhuan Zhang, Yingying Li, Xue Jiang, Zheng Dong, Yuanyuan Tao, Juan Du, Shuyao Wang, Teng Zhang, Na Du, Junyang Guo, Yaqiong Wu, Zehai Song, Haofei Luan, Yu Wang, Hongwen Du, Shaofeng Zhang, Chen Li, Hang Chang, Tao Wang
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Pharmacology Research & Perspectives
Subjects:
BBB
efflux transporter
microdialysis
permeability
unbound concentration
Online Access:https://doi.org/10.1002/prp2.575

Internet

https://doi.org/10.1002/prp2.575

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