The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes

The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes

eIF2B is a dedicated guanine nucleotide exchange factor for eIF2, the GTPase that is essential to initiate mRNA translation. The integrated stress response (ISR) signaling pathway inhibits eIF2B activity, attenuates global protein synthesis and upregulates a set of stress-response proteins. Partial...

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Bibliographic Details
Main Authors: Yao Liang Wong, Lauren LeBon, Rohinton Edalji, Hock Ben Lim, Chaohong Sun, Carmela Sidrauski
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
Integrated Stress Response
translation initiation
eIF2B
Vanishing White Matter Disease
Online Access:https://elifesciences.org/articles/32733

Internet

https://elifesciences.org/articles/32733

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