Cleavage of Oligonucleotides Containing a P3’→N5’ Phosphoramidate Linkage Mediated by Single-Stranded Oligonucleotide Templates

Cleavage of Oligonucleotides Containing a P3’→N5’ Phosphoramidate Linkage Mediated by Single-Stranded Oligonucleotide Templates

Double-stranded DNA (dsDNA) templates can hybridize to and accelerate cleavage of oligonucleotides containing a P3’→N5’ phosphoramidate (P-N) linkage. This dsDNA-templated cleavage of P-N linkages could be due to conformational strain placed on the linkage upon triplex formation. To determine whethe...

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Bibliographic Details
Main Authors: Takeshi Imanishi, Satoshi Obika, Futaba Makimura, Ayako Orita, Tomohisa Osaki, Noritsugu Hosoki, Tetsuya Kodama, Kosuke Ramon Ito
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:Molecules
Subjects:
bridged nucleic acids
DNA sensing
P3’→N5’ phosphoramidate
Online Access:http://www.mdpi.com/1420-3049/16/12/10695/

Internet

http://www.mdpi.com/1420-3049/16/12/10695/

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