Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS

Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS

Beta-defensins 2 and 3 (BD2 and BD3) are inducible peptides present at the sites of infection, and they are well characterized for their antimicrobial activities and immune-regulatory functions. However, no study has thoroughly investigated their immunomodulatory effects on macrophage-mediated immun...

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Bibliographic Details
Main Authors: Yongjian Wu, Dandan Li, Yi Wang, Xi Liu, Yuanqing Zhang, Wenting Qu, Kang Chen, Ngiambudulu M. Francisco, Lianqiang Feng, Xi Huang, Minhao Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
beta-defensins
Pseudomonas aeruginosa
macrophages
autophagy
bacterial eradication
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00211/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00211/full

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