Green Methodologies for Copper(I)-Catalyzed Azide-Alkyne Cycloadditions: A Comparative Study

Green Methodologies for Copper(I)-Catalyzed Azide-Alkyne Cycloadditions: A Comparative Study

Successful copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions may be achieved by several methods. In this paper, four synthetic protocols were performed for direct comparison of time required for the synthesis, yield, and purity of the 1H-1,2,3-triazole products. The methods with Cu(I)...

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Bibliographic Details
Main Authors: Marissa Trujillo, Clayton Hull-Crew, Andrew Outlaw, Kevin Stewart, Loren Taylor, Laura George, Allison Duensing, Breanna Tracey, Allen Schoffstall
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
1H-1,2,3-triazole
copper-catalyzed azide-alkyne cycloaddition (CuAAC)
microwave heating
solvent-free reaction
green chemistry
fluorotriazole
Online Access:http://www.mdpi.com/1420-3049/24/5/973

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http://www.mdpi.com/1420-3049/24/5/973

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