Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone–Treated Rats Are Not Affected by Chronic Imipramine Treatment: Possible Involvement of Enhanced 5-HT2A–Receptor Expression in the Frontal Cortex

Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone–Treated Rats Are Not Affected by Chronic Imipramine Treatment: Possible Involvement of Enhanced 5-HT2A–Receptor Expression in the Frontal Cortex

We examined the influence of imipramine, a traditional tricyclic antidepressant, on the binding to serotonin (5-HT)2receptors and levels of 5-HT2A–receptor mRNA in the frontal cortex of rats treated with adrenocorticotropic hormone (ACTH). Chronic treatment with ACTH significantly increased the bind...

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Main Authors: Yoshihisa Kitamura, Kazuhiko Shibata, Kozue Akiyama, Shizue Kimoto, Yoshika Fujitani, Kouhei Kitagawa, Hirotaka Kanzaki, Mamoru Ouchida, Kenji Shimizu, Hiromu Kawasaki, Toshiaki Sendo, Yutaka Gomita
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319315415
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spelling doaj-8396a498c99643dc8648f02bf041ad102020-11-25T02:20:48ZengElsevierJournal of Pharmacological Sciences1347-86132008-01-011061100106Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone–Treated Rats Are Not Affected by Chronic Imipramine Treatment: Possible Involvement of Enhanced 5-HT2A–Receptor Expression in the Frontal CortexYoshihisa Kitamura0Kazuhiko Shibata1Kozue Akiyama2Shizue Kimoto3Yoshika Fujitani4Kouhei Kitagawa5Hirotaka Kanzaki6Mamoru Ouchida7Kenji Shimizu8Hiromu Kawasaki9Toshiaki Sendo10Yutaka Gomita11Department of Pharmaceutical Care and Health Sciences, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan; Corresponding author. ykita@pheasant.pharm.okayama-u.ac.jpDepartment of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558 JapanDepartment of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558 JapanDepartment of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558 JapanDepartment of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558 JapanDepartment of Pharmaceutical Care and Health Sciences, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan; Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558 JapanDepartment of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho Okayama, 700-8558 JapanDepartment of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho Okayama, 700-8558 JapanDepartment of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho Okayama, 700-8558 JapanDepartment of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, JapanDepartment of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558 JapanDepartment of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558 JapanWe examined the influence of imipramine, a traditional tricyclic antidepressant, on the binding to serotonin (5-HT)2receptors and levels of 5-HT2A–receptor mRNA in the frontal cortex of rats treated with adrenocorticotropic hormone (ACTH). Chronic treatment with ACTH significantly increased the binding of [3H]-ketanserin to 5-HT2receptors and the expression of 5-HT2A–receptor mRNA in the frontal cortex. However, it did not alter the concentration of 5-HT or 5-hydroxyindole acetic acid. The effect of chronic ACTH treatment on 5-HT2receptor and 5-HT2A–receptor mRNA levels was not altered by the chronic administration of imipramine. Also, imipramine did not affect the hyperfunction of 5-HT2Areceptors caused by chronic ACTH treatment. These findings suggest that chronic treatment with ACTH acts to increase 5-HT2A– receptor synthesis through increased gene transcription, without modulating presynaptic serotonergic neurotransmission. Keywords:: 5-HT2Areceptor, adrenocorticotropic hormone, wet-dog shake, receptor binding, receptor mRNAhttp://www.sciencedirect.com/science/article/pii/S1347861319315415
collection DOAJ
language English
format Article
sources DOAJ
author Yoshihisa Kitamura
Kazuhiko Shibata
Kozue Akiyama
Shizue Kimoto
Yoshika Fujitani
Kouhei Kitagawa
Hirotaka Kanzaki
Mamoru Ouchida
Kenji Shimizu
Hiromu Kawasaki
Toshiaki Sendo
Yutaka Gomita
spellingShingle Yoshihisa Kitamura
Kazuhiko Shibata
Kozue Akiyama
Shizue Kimoto
Yoshika Fujitani
Kouhei Kitagawa
Hirotaka Kanzaki
Mamoru Ouchida
Kenji Shimizu
Hiromu Kawasaki
Toshiaki Sendo
Yutaka Gomita
Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone–Treated Rats Are Not Affected by Chronic Imipramine Treatment: Possible Involvement of Enhanced 5-HT2A–Receptor Expression in the Frontal Cortex
Journal of Pharmacological Sciences
author_facet Yoshihisa Kitamura
Kazuhiko Shibata
Kozue Akiyama
Shizue Kimoto
Yoshika Fujitani
Kouhei Kitagawa
Hirotaka Kanzaki
Mamoru Ouchida
Kenji Shimizu
Hiromu Kawasaki
Toshiaki Sendo
Yutaka Gomita
author_sort Yoshihisa Kitamura
title Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone–Treated Rats Are Not Affected by Chronic Imipramine Treatment: Possible Involvement of Enhanced 5-HT2A–Receptor Expression in the Frontal Cortex
title_short Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone–Treated Rats Are Not Affected by Chronic Imipramine Treatment: Possible Involvement of Enhanced 5-HT2A–Receptor Expression in the Frontal Cortex
title_full Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone–Treated Rats Are Not Affected by Chronic Imipramine Treatment: Possible Involvement of Enhanced 5-HT2A–Receptor Expression in the Frontal Cortex
title_fullStr Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone–Treated Rats Are Not Affected by Chronic Imipramine Treatment: Possible Involvement of Enhanced 5-HT2A–Receptor Expression in the Frontal Cortex
title_full_unstemmed Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone–Treated Rats Are Not Affected by Chronic Imipramine Treatment: Possible Involvement of Enhanced 5-HT2A–Receptor Expression in the Frontal Cortex
title_sort increased doi-induced wet-dog shakes in adrenocorticotropic hormone–treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-ht2a–receptor expression in the frontal cortex
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2008-01-01
description We examined the influence of imipramine, a traditional tricyclic antidepressant, on the binding to serotonin (5-HT)2receptors and levels of 5-HT2A–receptor mRNA in the frontal cortex of rats treated with adrenocorticotropic hormone (ACTH). Chronic treatment with ACTH significantly increased the binding of [3H]-ketanserin to 5-HT2receptors and the expression of 5-HT2A–receptor mRNA in the frontal cortex. However, it did not alter the concentration of 5-HT or 5-hydroxyindole acetic acid. The effect of chronic ACTH treatment on 5-HT2receptor and 5-HT2A–receptor mRNA levels was not altered by the chronic administration of imipramine. Also, imipramine did not affect the hyperfunction of 5-HT2Areceptors caused by chronic ACTH treatment. These findings suggest that chronic treatment with ACTH acts to increase 5-HT2A– receptor synthesis through increased gene transcription, without modulating presynaptic serotonergic neurotransmission. Keywords:: 5-HT2Areceptor, adrenocorticotropic hormone, wet-dog shake, receptor binding, receptor mRNA
url http://www.sciencedirect.com/science/article/pii/S1347861319315415
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