Spatiotemporal Alterations in Gait in Humanized Transgenic Sickle Mice

Spatiotemporal Alterations in Gait in Humanized Transgenic Sickle Mice

Sickle cell disease (SCD) is a hemoglobinopathy affecting multiple organs and featuring acute and chronic pain. Purkinje cell damage and hyperalgesia have been demonstrated in transgenic sickle mice. Purkinje cells are associated with movement and neural function which may influence pain. We hypothe...

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Bibliographic Details
Main Authors: Stacy Kiven, Ying Wang, Anupam Aich, Donovan A. Argueta, Jianxun Lei, Varun Sagi, Madhushan Tennakoon, Saad J. Bedros, Nils Lambrecht, Kalpna Gupta
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
purkinje cell
sickle cell disease
gait
hyperalgesia
histopathology
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.561947/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.561947/full

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