Prolonged Exposure of Cortical Neurons to Oligomeric Amyloid-β Impairs NMDA Receptor Function Via NADPH Oxidase-Mediated ROS Production: Protective Effect of Green Tea (-)-Epigallocatechin-3-Gallate

Prolonged Exposure of Cortical Neurons to Oligomeric Amyloid-β Impairs NMDA Receptor Function Via NADPH Oxidase-Mediated ROS Production: Protective Effect of Green Tea (-)-Epigallocatechin-3-Gallate

Excessive production of Aβ (amyloid β-peptide) has been shown to play an important role in the pathogenesis of AD (Alzheimer's disease). Although not yet well understood, aggregation of Aβ is known to cause toxicity to neurons. Our recent study demonstrated the ability for oligomeric Aβ to stim...

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Bibliographic Details
Main Authors: Yan He, Jiankun Cui, James C-M Lee, Shinghua Ding, Malgorzata Chalimoniuk, Agnes Simonyi, Albert Y Sun, Zezong Gu, Gary A Weisman, W Gibson Wood, Grace Y Sun
Format: Article
Language:English
Published: SAGE Publishing 2011-01-01
Series:ASN Neuro
Online Access:https://doi.org/10.1042/AN20100025

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https://doi.org/10.1042/AN20100025

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