Structure-Based Discovery of ABCG2 Inhibitors: A Homology Protein-Based Pharmacophore Modeling and Molecular Docking Approach

Structure-Based Discovery of ABCG2 Inhibitors: A Homology Protein-Based Pharmacophore Modeling and Molecular Docking Approach

ABCG2 is an ABC membrane protein reverse transport pump, which removes toxic substances such as medicines out of cells. As a result, drug bioavailability is an unexpected change and negatively influences the ADMET (absorption, distribution, metabolism, excretion, and toxicity), leading to multi-drug...

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Bibliographic Details
Main Authors: Minh-Tri Le, Viet-Nham Hoang, Dac-Nhan Nguyen, Thi-Hoang-Linh Bui, Thien-Vy Phan, Phuong Nguyen-Hoai Huynh, Thanh-Dao Tran, Khac-Minh Thai
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
ABCG2 inhibitors
protein reverse transport pump
homology protein
pharmacophore models
molecular docking
Online Access:https://www.mdpi.com/1420-3049/26/11/3115

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https://www.mdpi.com/1420-3049/26/11/3115

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