Underestimation of airway luminal eosinophilia by quantitative sputum cytometry

Abstract Rationale On Wright-stained sputum cytospins, eosinophil differential of ≥ 1.2% is considered abnormal, and ≥ 2.3% identifies an eosinophilic endotype. We hypothesized that failure to consider free eosinophil granules (FEG), and the re-emergence (unmasking) of eosinophilia due to various re...

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Bibliographic Details
Main Authors: Melanie Kjarsgaard, Adil Adatia, Anurag Bhalla, Nicola LaVigne, Katherine Radford, Chynna Huang, Manali Mukherjee, Parameswaran Nair
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Allergy, Asthma & Clinical Immunology
Subjects:
Online Access:https://doi.org/10.1186/s13223-021-00567-w