A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA.

A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA.

Therapeutic oligonucleotides including siRNA and immunostimulatory ligands of Toll-like receptors (TLR) or RIG-I like helicases (RLH) are a promising novel class of drugs. They are in clinical development for a broad spectrum of applications, e.g. as adjuvants in vaccines and for the immunotherapy o...

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Bibliographic Details
Main Authors: Christoph Coch, Christian Lück, Anna Schwickart, Bastian Putschli, Marcel Renn, Tobias Höller, Winfried Barchet, Gunther Hartmann, Martin Schlee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3733725?pdf=render

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http://europepmc.org/articles/PMC3733725?pdf=render

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