Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats

Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats

Triptolide (TP), a diterpenoid isolated from Tripterygium wilfordii Hook F, has an excellent pharmacological profile of immunosuppression and anti-tumor activities, but its clinical applications are severely restricted due to its severe and cumulative toxicities. The farnesoid X receptor (FXR) is th...

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Bibliographic Details
Main Authors: Jing Yang, Lixin Sun, Lu Wang, Hozeifa M. Hassan, Xuan Wang, Phillip B. Hylemon, Tao Wang, Huiping Zhou, Luyong Zhang, Zhenzhou Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
triptolide
hepatotoxicity
bile acid metabolism
hepatic gluconeogenesis
farnesoid X receptor
Sirtuin 1
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00260/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00260/full

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