Bile salt metabolism is not the only factor contributing to Clostridioides (Clostridium) difficile disease severity in the murine model of disease

Bile salt metabolism is not the only factor contributing to Clostridioides (Clostridium) difficile disease severity in the murine model of disease

Susceptibility of patients to antibiotic-associated C. difficile disease is intimately associated with specific changes to gut microbiome composition. In particular, loss of microbes that modify bile salt acids (BSA) play a central role; primary bile acids stimulate spore germination whilst secondar...

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Bibliographic Details
Main Authors: Caitlin A. Jukes, Umer Zeeshan Ijaz, Anthony Buckley, Janice Spencer, June Irvine, Denise Candlish, Jia V. Li, Julian R. Marchesi, Gillian Douce
Format: Article
Language:English
Published: Taylor & Francis Group 2020-05-01
Series:Gut Microbes
Subjects:
bile salt metabolism
clostridium difficile
germination
antibiotics
disease severity
Online Access:http://dx.doi.org/10.1080/19490976.2019.1678996

Internet

http://dx.doi.org/10.1080/19490976.2019.1678996

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