Stimulation of Tetrahydrobiopterin Synthesis by Cyclosporin A during Lipopolysaccharide Treatment in Vascular Endothelial Cells

Stimulation of Tetrahydrobiopterin Synthesis by Cyclosporin A during Lipopolysaccharide Treatment in Vascular Endothelial Cells

We examined the effect of immunosuppressant cyclosporin A (CsA) on the synthesis of tetrahydrobiopterin (BH4), which is a cofactor for nitric oxide synthase (NOS), during treatment with lipopolysaccharide (LPS) in mouse brain microvascular endothelial cells. Addition of LPS to the endothelial cells...

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Bibliographic Details
Main Authors: Ishii Masakazu, Shimizu Shunichi, Shiota Kazuhiro, Yamamoto Shinichiro, Kiuchi Yuji, Yamamoto Toshinori
Format: Article
Language:English
Published: De Gruyter 2002-08-01
Series:Pteridines
Subjects:
cyclosporin a
tetrahydrobiopterin
gtp-cyclohydrolase i
lipopolysaccharide
mouse brain microvascular endothelial cells
Online Access:https://doi.org/10.1515/pteridines.2002.13.3.89

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https://doi.org/10.1515/pteridines.2002.13.3.89

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