Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE

Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE

Aldehyde dehydrogenase 2 (ALDH2) is an enzyme that detoxifies reactive oxygen species (ROS)-generated aldehyde adducts such as 4-hydroxy-trans-2-nonenal (4-HNE). Previous meta-analyses have shown an increase in the risk of atrial fibrillation (AF) in patients with chronic alcohol consumption. <i&...

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Bibliographic Details
Main Authors: Lung-An Hsu, Feng-Chun Tsai, Yung-Hsin Yeh, Chi-Jen Chang, Chi-Tai Kuo, Wei-Jan Chen, Hsin-Yi Tsai, Gwo-Jyh Chang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
atrial fibrillation
aldehyde dehydrogenase 2
polymorphism
Online Access:https://www.mdpi.com/1422-0067/21/18/6678

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https://www.mdpi.com/1422-0067/21/18/6678

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