Shifting the Immune-Suppressive to Predominant Immune-Stimulatory Radiation Effects by SBRT-PArtial Tumor Irradiation Targeting HYpoxic Segment (SBRT-PATHY)

Shifting the Immune-Suppressive to Predominant Immune-Stimulatory Radiation Effects by SBRT-PArtial Tumor Irradiation Targeting HYpoxic Segment (SBRT-PATHY)

Radiation-induced immune-mediated abscopal effects (AE) of conventional radiotherapy are very rare. Whole-tumor irradiation leads to lymphopenia due to killing of immune cells in the tumor microenvironment, resulting in immunosuppression and weak abscopal potential. This limitation may be overcome b...

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Bibliographic Details
Main Authors: Slavisa Tubin, Seema Gupta, Michael Grusch, Helmuth H. Popper, Luka Brcic, Martin L. Ashdown, Samir N. Khleif, Barbara Peter-Vörösmarty, Martin Hyden, Simone Negrini, Piero Fossati, Eugen Hug
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
immune-microenvironment
partial irradiation
abscopal effect
bystander effect
SBRT
timing
Online Access:https://www.mdpi.com/2072-6694/13/1/50

Internet

https://www.mdpi.com/2072-6694/13/1/50

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