Augmentation of Saporin-Based Immunotoxins for Human Leukaemia and Lymphoma Cells by Triterpenoid Saponins: The Modifying Effects of Small Molecule Pharmacological Agents

Augmentation of Saporin-Based Immunotoxins for Human Leukaemia and Lymphoma Cells by Triterpenoid Saponins: The Modifying Effects of Small Molecule Pharmacological Agents

Triterpenoid saponins from <i>Saponinum album</i> (SA) significantly augment the cytotoxicity of saporin-based immunotoxins but the mechanism of augmentation is not fully understood. We investigated the effects of six small molecule pharmacological agents, which interfere with endocytic...

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Bibliographic Details
Main Authors: Wendy S. Smith, David A. Johnston, Suzanne E. Holmes, Harrison J. Wensley, Sopsamorn U. Flavell, David J. Flavell
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Toxins
Subjects:
saporin
immunotoxin
augmentation
saponin
endocytosis
reactive oxygen species
Online Access:https://www.mdpi.com/2072-6651/11/2/127

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https://www.mdpi.com/2072-6651/11/2/127

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