Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease
Altered neuronal activity in the striatum appears to be a key component of Huntington's disease (HD), a fatal, neurodegenerative condition. To assess this hypothesis in freely behaving transgenic rats that model HD (tgHDs), we used chronically implanted micro-wires to record the spontaneous act...
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Elsevier
2010-01-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996109002654 |
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doaj-832f3bf1d2f9480dbbcac6cb84115aa22021-03-20T04:58:21ZengElsevierNeurobiology of Disease1095-953X2010-01-01371106113Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's diseaseBenjamin R. Miller0Adam G. Walker1Stephen C. Fowler2Stephan von Hörsten3Olaf Riess4Michael A. Johnson5George V. Rebec6Program in Neuroscience and Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USAProgram in Neuroscience and Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USADepartment of Pharmacology and Toxicology and Life Span Institute, University of Kansas, Lawrence, KS 66045, USADepartment of Experimental Therapy, Franz-Penzoldt-Center, Friedrich-Alexander-University Erlangen-Nürnbuerg, GermanyDepartment of Medical Genetics, University of Tubingen, Tubingen, GermanyDepartment of Chemistry, University of Kansas, Lawrence, KS 66045, USAProgram in Neuroscience and Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA; Corresponding author. Program in Neuroscience, 1101 East 10th St., Bloomington, IN 47405, USA. Fax: +1 812 4520.Altered neuronal activity in the striatum appears to be a key component of Huntington's disease (HD), a fatal, neurodegenerative condition. To assess this hypothesis in freely behaving transgenic rats that model HD (tgHDs), we used chronically implanted micro-wires to record the spontaneous activity of striatal neurons. We found that relative to wild-type controls, HD rats suffer from population-level deficits in striatal activity characterized by a loss of correlated firing and fewer episodes of coincident spike bursting between simultaneously recorded neuronal pairs. These results are in line with our previous report of marked alterations in the pattern of striatal firing in mouse models of HD that vary in background strain, genetic construct, and symptom severity. Thus, loss of coordinated spike activity in striatum appears to be a common feature of HD pathophysiology, regardless of HD model variability.http://www.sciencedirect.com/science/article/pii/S0969996109002654Huntington's diseaseTransgenicRatStriatumMedium spiny neuronsElectrophysiology |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Benjamin R. Miller Adam G. Walker Stephen C. Fowler Stephan von Hörsten Olaf Riess Michael A. Johnson George V. Rebec |
| spellingShingle |
Benjamin R. Miller Adam G. Walker Stephen C. Fowler Stephan von Hörsten Olaf Riess Michael A. Johnson George V. Rebec Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease Neurobiology of Disease Huntington's disease Transgenic Rat Striatum Medium spiny neurons Electrophysiology |
| author_facet |
Benjamin R. Miller Adam G. Walker Stephen C. Fowler Stephan von Hörsten Olaf Riess Michael A. Johnson George V. Rebec |
| author_sort |
Benjamin R. Miller |
| title |
Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease |
| title_short |
Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease |
| title_full |
Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease |
| title_fullStr |
Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease |
| title_full_unstemmed |
Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease |
| title_sort |
dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model huntington's disease |
| publisher |
Elsevier |
| series |
Neurobiology of Disease |
| issn |
1095-953X |
| publishDate |
2010-01-01 |
| description |
Altered neuronal activity in the striatum appears to be a key component of Huntington's disease (HD), a fatal, neurodegenerative condition. To assess this hypothesis in freely behaving transgenic rats that model HD (tgHDs), we used chronically implanted micro-wires to record the spontaneous activity of striatal neurons. We found that relative to wild-type controls, HD rats suffer from population-level deficits in striatal activity characterized by a loss of correlated firing and fewer episodes of coincident spike bursting between simultaneously recorded neuronal pairs. These results are in line with our previous report of marked alterations in the pattern of striatal firing in mouse models of HD that vary in background strain, genetic construct, and symptom severity. Thus, loss of coordinated spike activity in striatum appears to be a common feature of HD pathophysiology, regardless of HD model variability. |
| topic |
Huntington's disease Transgenic Rat Striatum Medium spiny neurons Electrophysiology |
| url |
http://www.sciencedirect.com/science/article/pii/S0969996109002654 |
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