Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease

Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease

Altered neuronal activity in the striatum appears to be a key component of Huntington's disease (HD), a fatal, neurodegenerative condition. To assess this hypothesis in freely behaving transgenic rats that model HD (tgHDs), we used chronically implanted micro-wires to record the spontaneous act...

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Bibliographic Details
Main Authors: Benjamin R. Miller, Adam G. Walker, Stephen C. Fowler, Stephan von Hörsten, Olaf Riess, Michael A. Johnson, George V. Rebec
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Transgenic
Rat
Striatum
Medium spiny neurons
Electrophysiology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002654

Internet

http://www.sciencedirect.com/science/article/pii/S0969996109002654

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