Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes

Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes

Fragile X syndrome (FXS) is a common form of intellectual disability and autism caused by the lack of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved in RNA transport and protein synthesis. Upon cellular stress, global protein synthesis is blocked and mRNAs are recruited...

Full description

Bibliographic Details
Main Authors: B. Di Marco, P. Dell'Albani, S. D'Antoni, M. Spatuzza, C.M. Bonaccorso, S.A. Musumeci, F. Drago, B. Bardoni, M.V. Catania
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
Stress granules
mGlu5 receptor
FMRP
Fragile X syndrome
eIF2alpha
Astrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000875

Internet

http://www.sciencedirect.com/science/article/pii/S0969996121000875

Similar Items