Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

Although animal models of Alzheimer's disease (AD) recapitulate β-amyloid-dependent hippocampal synaptic and cognitive dysfunctions, it is poorly understood how cortex-dependent remote memory stabilization following initial hippocampal coding is affected. Here, we systematically analyzed biophy...

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Bibliographic Details
Main Authors: Ryoichi Kimura, Masuo Ohno
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Neurobiology of Disease
Subjects:
LTP
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002581