Effect of episomally encoded DNA polymerases on chemically induced mutagenesis at the hisG46 target in Ames test

Effect of episomally encoded DNA polymerases on chemically induced mutagenesis at the hisG46 target in Ames test

Abstract Background The standard Ames test strains owe their high sensitivity to chemical and physical mutagens to the episomal Y-family DNA polymerase RI encoded by the mucAB operon. The S. typhimurium test strains carry also another related samAB operon on a 60-kDa cryptic plasmid. In contrast to...

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Bibliographic Details
Main Authors: Petr Grúz, Masatomi Shimizu, Kei-ichi Sugiyama, Masami Yamada, Masamitsu Honma
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Genes and Environment
Subjects:
Ames test
DNA polymerase
samAB
Mutagenesis
Azide
pKM101
Online Access:http://link.springer.com/article/10.1186/s41021-020-00154-2

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http://link.springer.com/article/10.1186/s41021-020-00154-2

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