Discovery of Novel Integrase Inhibitors Acting outside the Active Site Through High-Throughput Screening

Discovery of Novel Integrase Inhibitors Acting outside the Active Site Through High-Throughput Screening

Currently, an increasing number of drugs are becoming available to clinics for the treatment of HIV infection. Even if this targeted therapy is highly effective at suppressing viral replication, caregivers are facing growing therapeutic failures in patients, due to resistance with or without treatme...

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Bibliographic Details
Main Authors: Cindy Aknin, Elena A. Smith, Christophe Marchand, Marie-Line Andreola, Yves Pommier, Mathieu Metifiot
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
hiv-1
insti resistance
dna-binding inhibitor
high-throughput screening
drug discovery
Online Access:https://www.mdpi.com/1420-3049/24/20/3675

Internet

https://www.mdpi.com/1420-3049/24/20/3675

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