Synthesis and crystal structures of three new benzotriazolylpropanamides

• Main Authors: Donna S. Amenta, Phil Liebing, Julia E. Biero, Robert J. Sherman, John W. Gilje, Frank T. Edelmann
• Format: Article
• Language: English
• Published: International Union of Crystallography 2017-06-01
• Series: Acta Crystallographica Section E: Crystallographic Communications
• Subjects: crystal structure; acrylamide; benzotriazole; benzotriazolylpropanamide; hydrogen bond; π–π stacking
• Online Access: http://scripts.iucr.org/cgi-bin/paper?S2056989017007472
• ISSN: 2056-9890

The base-catalyzed Michael addition of 2-methylacrylamide to benzotriazole afforded 3-(1H-benzotriazol-1-yl)-2-methylpropanamide, C10H12N4O (1), in 32% yield in addition to small amounts of isomeric 3-(2H-benzotriazol-2-yl)-2-methylpropanamide, C10H12N4O (2). In a similar manner, 3-(1H-benzotriazol-1-yl)-N,N-dimethylpropanamide, C11H14N4O (3), was prepared from benzotriazole and N,N-dimethylacrylamide. All three products have been structurally characterized by single-crystal X-ray diffraction. The crystal structures of 1 and 2 comprise infinite arrays formed by N—H...O and N—H...N bridges, as well as π–π interactions, while the molecules of 3 are aggregated to simple π-dimers in the crystal.