Comparison of different cell type correction methods for genome-scale epigenetics studies

Comparison of different cell type correction methods for genome-scale epigenetics studies

Abstract Background Whole blood is frequently utilized in genome-wide association studies of DNA methylation patterns in relation to environmental exposures or clinical outcomes. These associations can be confounded by cellular heterogeneity. Algorithms have been developed to measure or adjust for t...

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Bibliographic Details
Main Authors: Akhilesh Kaushal, Hongmei Zhang, Wilfried J. J. Karmaus, Meredith Ray, Mylin A. Torres, Alicia K. Smith, Shu-Li Wang
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Bioinformatics
Subjects:
Cell-type composition
CpG sites
Genome-scale DNA methylation
Surrogate variables
Online Access:http://link.springer.com/article/10.1186/s12859-017-1611-2

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http://link.springer.com/article/10.1186/s12859-017-1611-2

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