Loss of miR-145-5p Causes Ceruloplasmin Interference with PHD-Iron Axis and HIF-2α Stabilization in Lung Adenocarcinoma-Mediated Angiogenesis

Loss of miR-145-5p Causes Ceruloplasmin Interference with PHD-Iron Axis and HIF-2α Stabilization in Lung Adenocarcinoma-Mediated Angiogenesis

For decades, lung cancer has been the leading cause of cancer-related death worldwide. Hypoxia-inducible factors (HIFs) play critical roles in mediating lung cancer development and metastasis. The present study aims to clarify how HIF’s over-activation affects lung cancer angiogenesis not only in a...

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Bibliographic Details
Main Authors: Ying-Ming Tsai, Kuan-Li Wu, Yung-Yun Chang, Wei-An Chang, Yung-Chi Huang, Shu-Fang Jian, Pei-Hsun Tsai, Yi-Shiuan Lin, Inn-Wen Chong, Jen-Yu Hung, Ya-Ling Hsu
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
angiogenesis
ceruloplasmin
HIF-2α
lung cancer
miR-145-5p
Online Access:https://www.mdpi.com/1422-0067/21/14/5081

Internet

https://www.mdpi.com/1422-0067/21/14/5081

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