The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicators.

The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicators.

In eukaryotic chromosomes, DNA replication initiates at multiple origins. Large inter-origin gaps arise when several adjacent origins fail to fire. Little is known about how cells cope with this situation. We created a derivative of Saccharomyces cerevisiae chromosome III lacking all efficient origi...

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Bibliographic Details
Main Authors: James F Theis, Carmela Irene, Ann Dershowitz, Renee L Brost, Michael L Tobin, Fabiana M di Sanzo, Jian-Ying Wang, Charles Boone, Carol S Newlon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2996327?pdf=render

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http://europepmc.org/articles/PMC2996327?pdf=render

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