Multicomponent synthesis, biological evaluation and molecular docking of new spiro-oxindole derivatives
A new series of spiro-oxindoles that were identified based upon their ability to inhibit methionine tRNA synthase (PDB ID: 1PFV) and glucosamine-6-phosphate synthase (PDB ID: 1JXA) enzymes in virtual screening was synthesized by a three-component 1,3-dipolar cycloaddition method. The reaction procee...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-11-01
|
| Series: | Journal of Taibah University for Science |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1658365517300675 |