G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic

G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic

Abstract Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a progressive neurodegenerative disease caused by point mutations in the gene for neuroserpin, a serine protease inhibitor of the nervous system. Different mutations are known that are responsible for mutant neuroserpin po...

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Bibliographic Details
Main Authors: Thies Ingwersen, Christian Linnenberg, Emanuela D’Acunto, Shabnam Temori, Irene Paolucci, David Wasilewski, Behnam Mohammadi, Johannes Kirchmair, Robert C. Glen, Elena Miranda, Markus Glatzel, Giovanna Galliciotti
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88090-1

Internet

https://doi.org/10.1038/s41598-021-88090-1

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