FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway

FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway

Abstract Background Long non-coding RNAs (lncRNAs) are extensively intricate in the tumorigenesis and metastasis of various cancer types. Nevertheless, the detailed molecular mechanisms of lncRNA in non-small cell lung cancer (NSCLC) still remain mainly undetermined. Methods qPCR was performed to ve...

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Bibliographic Details
Main Authors: Cheng-Cao Sun, Wei Zhu, Shu-Jun Li, Wei Hu, Jian Zhang, Yue Zhuo, Han Zhang, Juan Wang, Yu Zhang, Shao-Xin Huang, Qi-Qiang He, De-Jia Li
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Genome Medicine
Subjects:
LINC00301
ELL protein-associated factor 2 (EAF2)
Non-small cell lung cancer (NSCLC)
Enhancer of zeste homolog 2 (EZH2)
Regulatory T cells (Treg)
Hypoxia-inducible factor 1 α (HIF1α)
Online Access:http://link.springer.com/article/10.1186/s13073-020-00773-y

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http://link.springer.com/article/10.1186/s13073-020-00773-y

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