Functional pathway analysis using SCNP of FLT3 receptor pathway deregulation in AML provides prognostic information independent from mutational status.

Functional pathway analysis using SCNP of FLT3 receptor pathway deregulation in AML provides prognostic information independent from mutational status.

FMS-like tyrosine kinase 3 receptor (FLT3) internal tandem duplication (ITD) mutations result in constitutive activation of this receptor and have been shown to increase the risk of relapse in patients with acute myeloid leukemia (AML); however, substantial heterogeneity in clinical outcomes still e...

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Main Authors: Alessandra Cesano, Santosh Putta, David B Rosen, Aileen C Cohen, Urte Gayko, Kavita Mathi, John Woronicz, Rachael E Hawtin, Larry Cripe, Zhuoxin Sun, Martin S Tallman, Elisabeth Paietta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3576376?pdf=render

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