Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury

Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury

We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the parietal cortex in male adult mice. We investigated if...

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Bibliographic Details
Main Authors: Chase M. Carver, Haley R. DeWitt, Aiola P. Stoja, Mark S. Shapiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Neuroscience
Subjects:
ion channels
TRPC channels
hippocampus
epilepsy
seizure
traumatic brain injury
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.681144/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.681144/full

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