Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye.

Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye.

Innovative protein engineering and chemical conjugation technologies have yielded an impressive number of drug candidates in clinical development including >80 antibody drug conjugates, >60 bispecific antibodies, >35 Fc-fusion proteins and >10 immuno-cytokines. Despite these innovations,...

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Bibliographic Details
Main Authors: Whitney Shatz, Philip E Hass, Nikhil Peer, Maciej T Paluch, Craig Blanchette, Guanghui Han, Wendy Sandoval, Ashley Morando, Kelly M Loyet, Vladimir Bantseev, Helen Booler, Susan Crowell, Amrita Kamath, Justin M Scheer, Robert F Kelley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0218613

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https://doi.org/10.1371/journal.pone.0218613

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