The Destructive Action of IL-1α and IL-1β in IDDM is a Multistage Process: Evidence and Confirmation by Apoptotic Studies, Induction of Intermediates and Electron Microscopy

Using the rat β-cell RIN-5AH insulinoma line as a means for studying insulin-dependent diabetes mellitus (IDDM), it is shown that interleukin-1 (IL-1) induces β-cell damage initiated by early apoptotic signals. This action is demonstrated by DNA fragmentation, as assessed by specific BrdU labeling,...

Full description

Bibliographic Details
Main Authors: S. Vassiliadis, V. Dragiotis, E. Protopapadakis, I. Athanassakis, P. Mitlianga, K. Konidaris, G. K. Papadopoulos
Format: Article
Language:English
Published: Hindawi Limited 1999-01-01
Series:Mediators of Inflammation
Subjects:
Fas
PKC
Online Access:http://dx.doi.org/10.1080/09629359990577