Triarylmethanes, a new class of Cx50 inhibitors

Triarylmethanes, a new class of Cx50 inhibitors

The paucity of specific pharmacological agents has been a major impediment for delineating the roles of gap junction channels formed by connexin proteins in physiology and pathophysiology. Here, we used the selective optimization of side activities (SOSA) approach, which has led to the design of hig...

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Bibliographic Details
Main Authors: SILKE eBODENDIEK, CLIO eRUBINOS, MARIA PILAR TRELLES, DAVID eJENKINS, NICHOLE eCOLEMAN, Heike eWulff, MIDUTURU eSRINIVAS
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Pharmacology
Subjects:
Gap Junctions
ion channel
triarylmethane
inhibitors
Structure-activity-relationship
lens epithelial cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00106/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00106/full

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