Maternal sitagliptin treatment attenuates offspring glucose metabolism and intestinal proinflammatory cytokines IL-6 and TNF-α expression in male rats

Maternal sitagliptin treatment attenuates offspring glucose metabolism and intestinal proinflammatory cytokines IL-6 and TNF-α expression in male rats

Increasing evidence shows that maternal overnutrition may increase the risk of diabetes in offspring. We hypothesized that maternal sitagliptin intervention may improve glucose intolerance through gut targeting. Female Sprague-Dawley (SD) rats were fed a normal diet (ND) or a high-fat diet (HFD) for...

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Bibliographic Details
Main Authors: Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Format: Article
Language:English
Published: PeerJ Inc. 2020-11-01
Series:PeerJ
Subjects:
Sitagliptin
Fetal programming
Inflammatory
Maternal diet
Intestine
Online Access:https://peerj.com/articles/10310.pdf

Internet

https://peerj.com/articles/10310.pdf

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