IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

Summary: Autophagy plays a broad role in health and disease. Here, we show that inositol polyphosphate multikinase (IPMK) is a prominent physiological determinant of autophagy and is critical for liver inflammation and regeneration. Deletion of IPMK diminishes autophagy in cell lines and mouse liver...

Full description

Bibliographic Details
Main Authors: Prasun Guha, Richa Tyagi, Sayan Chowdhury, Luke Reilly, Chenglai Fu, Risheng Xu, Adam C. Resnick, Solomon H. Snyder
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719301755

Internet

http://www.sciencedirect.com/science/article/pii/S2211124719301755

Similar Items